What Is Rejuran and How Does Rejuran Injection Benefit Your Skin?

In the ever-evolving field of aesthetic medicine, Rejuran has become one of the most sought-after treatments for skin rejuvenation and repair. Using advanced polynucleotide (PN) technology, Rejuran helps revitalize the skin from within by improving elasticity, smoothing fine lines, and enhancing overall skin health.

Unlike traditional injectables that focus on adding volume or paralyzing muscles, Rejuran’s approach is regenerative—encouraging the skin to heal and rebuild itself for long-term improvement.

What Is Rejuran?

A Regenerative Approach to Skin Rejuvenation

Rejuran is an injectable skin treatment that utilizes polynucleotides (PN)—fragments of DNA extracted from salmon DNA—to stimulate the skin’s natural healing and repair processes. These PNs are biocompatible and safe for human use, making them highly effective in improving skin elasticity, hydration, and texture.

Polynucleotides play a key role in stimulating collagen production and enhancing cellular regeneration, which in turn strengthens the skin’s structure and promotes smoother, healthier skin. Over time, this process helps minimize the appearance of fine lines, wrinkles, and rough texture, creating a more youthful and radiant complexion.

How Rejuran Differs from Other Injectables

While treatments like Botox and dermal fillers focus on reducing wrinkles or restoring volume, Rejuran’s main goal is to repair and rejuvenate the skin itself. Botox temporarily relaxes muscles to smooth expression lines, and fillers add volume to areas like the cheeks or lips. Rejuran, on the other hand, revitalizes the skin’s condition from the inside out by promoting tissue repair and increasing collagen density. It’s a treatment that enhances long-term skin health rather than providing temporary cosmetic correction.

How Does Rejuran Injection Work for Skin?

The Science Behind Rejuran’s Effectiveness

Rejuran works by delivering polynucleotides directly into the dermis layer of the skin through a series of microinjections. Once injected, these PNs activate the body’s natural regeneration mechanisms, stimulating fibroblast activity—the process responsible for producing collagen, elastin, and extracellular matrix proteins. This helps to repair damaged skin cells and restore structural integrity, resulting in firmer, smoother, and more youthful-looking skin.

Treatment Areas and Visible Benefits

Rejuran is most commonly used on the face, neck, and hands—areas that are prone to early signs of aging and environmental damage. The treatment effectively targets:

After a few sessions, patients often notice improved hydration, firmness, and tone, as well as a radiant glow that continues to enhance over time.

Strengthening the Skin Barrier

Beyond cosmetic benefits, Rejuran helps restore the skin’s protective barrier, making it more resilient against pollutants, UV damage, and other external stressors. This repair process improves overall skin health and longevity, giving a balanced, natural appearance rather than a “filled” look.

How Long Does Rejuran Last?

Duration of Effects

The results from Rejuran are not immediate but develop progressively as the skin regenerates. Most patients begin noticing improvements in skin smoothness and hydration within two to four weeks after the initial treatment. Optimal results usually appear after completing a series of three to four sessions, spaced about one month apart.

Once the full course is completed, results typically last around 6 to 12 months, depending on factors like age, lifestyle, and skin condition.

Factors Affecting Longevity

Individual skin type, metabolism, and aftercare all play a role in how long results last. Maintaining a consistent skincare routine, staying hydrated, and minimizing UV exposure can help prolong the benefits of the treatment.

Recommended Re-treatment Schedule

To maintain optimal results, practitioners often recommend maintenance sessions every 6 to 9 months, allowing the skin to continue regenerating and sustaining collagen production over time.

What to Expect Before, During, and After Rejuran Treatment

Consultation and Assessment

Before undergoing Rejuran, patients consult with a qualified aesthetic professional to assess skin type, treatment areas, and desired results. The practitioner will determine whether Rejuran is suitable and may combine it with complementary procedures for enhanced outcomes.

The Procedure

The procedure is minimally invasive and typically takes 30 to 45 minutes. Using a fine needle or microinjector device, small amounts of Rejuran are injected across the targeted areas. Some patients may experience mild redness or swelling immediately after the treatment, which generally subsides within a day or two.

Post-Treatment Care

After treatment, patients are advised to avoid sun exposure, alcohol, and strenuous activity for 24–48 hours. Gentle skincare and hydration are essential during recovery. Results gradually appear as the skin begins its repair cycle, usually within a few weeks.

Possible Side Effects

Common side effects are mild and temporary, including slight redness, pinpoint swelling, or tenderness at the injection sites. These effects typically resolve quickly without the need for downtime.

Who Are the Ideal Candidates for Rejuran?

Age Group

Rejuran is suitable for adults of various age groups who wish to improve skin texture and slow down aging. It’s particularly beneficial for individuals in their late 20s to 50s, when collagen production naturally declines, leading to fine lines and loss of elasticity.

Skin Conditions and Concerns

Rejuran is ideal for those struggling with:

It is also an excellent option for patients seeking a preventative skin rejuvenation treatment, as it boosts long-term dermal health.

Conclusion

Rejuran injection represents a major advancement in regenerative aesthetics—designed to repair, rejuvenate, and restore skin health at the cellular level. By stimulating collagen production and enhancing the skin’s natural healing abilities, Rejuran delivers long-lasting improvements in texture, tone, and hydration.

If you’re looking for a treatment that focuses on true skin renewal, consult with a trusted aesthetic professional to learn how Rejuran can help you achieve smoother, younger-looking skin with natural, radiant results.